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DSIP administration did not significantly affect corticotropin-releasing-hormone (CRH)-stimulated or meal-induced ACTH and cortisol secretion, indicating thatcontrary to stress-protective effects reported in some animal studiesDSIP does not measurably blunt the human cortisol response

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It is also imperative to consider the effects of sleep deprivation and to evaluate changes in these indices following treatments such as continuous positive airway pressure (CPAP) and estrogen therapy

Claussnitzer M, Dankel SN, Kim K-H, Quon G, Meuleman W, Haugen C, et al