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CSCs have long been considered as the main culprit for drug resistance and relapse (MacDonagh et al., 2016

[Google Scholar] 78.Huwiler V.V., Maissen-Abgottspon S., Stanga Z., Mhlebach S., Trepp R., Bally L., Bano A

The ubiquitously expressed pyruvate dehydrogenase (PDH) carries pyruvate, via pyruvate dehydrogenation and formation of acetyl Coenzyme A, into the TCA cycle in both neurons and astrocytes, but no new TCA cycle intermediate is generated by the action of this enzyme alone

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