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2) independent of Ca 2+ , as even ionomycin-induced eryptosis (ionomycin is a Ca 2+ ionophore) is attenuated by NO donor nitroprusside [170]
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DOI: 10.1155/2010/938640 27
This has sparked interest in its use for extending healthspan.(7) Activation of AMPK Pathway: Metformin activates AMPK (AMP-activated protein kinase), a key cellular energy sensor that promotes repair processes and mimics some benefits of calorie restriction
