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An 8-week treadmill exercise at 70%85% VO 2 max significantly downregulated the levels of TFR1, TF, DMT1, FTL, FTH, mitochondrial Ferritin, -secretase, and APP in the cortical motor regions of aged amyloid precursor protein-C105 (APP-C105) mice, upregulated the expression of FPN1, Furin, and -secretase, significantly reduced Fe 2+ , Fe 3+ , and total iron content, inhibited brain iron accumulation and A plaque growth, thereby improving learning ability, memory, and cognitive function in aged APP-C105 mice (Choi et al., 2021)

Average lifespan has being (hopefully) continuously growing: from ~27 years in the Greco-Roman era, to ~47 years in 1900, and ~77 years by the end of 20 th century [235]

The loss of GSH disrupts redox homeostasis, leading to ROS accumulation and, subsequently, cellular dysfunction and death [10]

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This trial presented positive results, whereas the larger longterm randomized controlled trials are needed to confirm the therapeutic effect of trimetazidine on amyotrophic lateral sclerosis