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In addition, SD rats were dosed orally for 2 years at 10, 20, 40, and 60 mg/kg/day (3 to 19 times the oral MRHD based on mg/m2)

MFSeI [1-methyl-3-(phenylselenyl)-1H indole] exerts antidepressant and anti-anxiety effects by reducing OS, regulating neurotransmitter balance, and affecting glucocorticoid receptor expression (Bampi et al., 2020)

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Secondary ( n = 3), tertiary ( n = 4), and quaternary N-glucuronides ( n = 2) included in our assessment exhibited on average a slightly higher relative mean shift in TW CCS N2, meas (+ 41.7 7.5 2 ) compared to the investigated O-glucuronides (+ 38.1 8.9 2 ) with almost identical SDs (Table 1 and Fig

People with underlying heart disease, AFib, or hyperthyroidism may be especially sensitive

doi: 10.1002/ptr.2634 19