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For more on how PCOS and insulin resistance connect to nutritional status, see our guide on insulin resistance and PCOS

While vitamin B12 is generally safe, unnecessary supplementation should be avoided

Studies in this systematic review support B12 supplementation for the treatment or prevention of metformin-induced deficiency and neuropathy, demonstrating increased levels of B12 and decreased serum homocysteine with supplementation

No other exclusion criterion was used to better maximize the external validity of our findings

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But this pregnancy hormone has found a second life in men's health, specifically for testosterone support and fertility preservation