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SECOND-LINE TREATMENT Methotrexate Second-line agents are useful especially if a patient experiences undesirable ADRs or is resistant to GCs

But mechanisms don't always translate cleanly from bench to bedside

MRP1 is involved in inflammation, detoxification and oxidative stress 1,2

Phosphoenolpyruvate + ADP + H + Pyruvate + ATP Therefore, during the glycolytic pathway, two molecules of pyruvate are produced from a glucose molecule

Acute kidney injury secondary to exposure to insecticides used for bedbug (Cimex lectularis) control

Knowing what to look for helps you catch problems that have progressed beyond the invisible chemistry stage into obvious physical changes