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192 , 5659 (2011) Thompson, R.A., Isin, E.M., Li, Y., Weaver, R., Weidolf, L., Wilson, I., Claesson, A., Page, K., Dolgos, H., Kenna, J.G.: Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

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For bioinformatics analysis, data normalization was conducted using the Trimmed Mean of M -values method in edgeR, and pathway analyses were performed with Fishers exact test

Injecting in a fed state reduces efficacy by 3040% because elevated insulin suppresses hormone-sensitive lipase, preventing fatty acid release from adipocytes

In the mitochondrial compartment, however, a dedicated HSP100 family disaggregase operates: CLPB (also known as SKD3)

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