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Mitochondrial antioxidant proteins in the first line of defense against ROS/RNS fall into three categories, including non-enzymatic antioxidants (i.e., GSH), direct enzymatic antioxidants (i.e., SOD2 and GPx), and indirect enzymatic antioxidants [i.e., glutathione reductases (GR), peroxiredoxins, and thioredoxins (Trx)] [96, 97]

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Thiol-induced hemoglobin oxidation