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Glutathione S -conjugate formation with haloalkenes is catalyzed by both microsomal (MGST1) and cytosolic GSTs in ratios that depend to some extent on the structure of the haloalkene (Cooper and Pinto, 2008 and references cited therein)

doi: 10.1152/jappl.1994.76.6.2570

The increased activity of HK and PFK not only enhances glycolysis in tumor cells but is also associated with the expression of immune checkpoint molecules, such as the upregulation of PD-L1

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Furthermore, the GH and IGF system components are also locally produced by cancer cells and exert both autocrine and paracrine roles increasing the complexity of the global framework (2)

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