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In this type of system, causal relationships are complex, as feedback mechanisms may turn effects into causes, as for example in the case of the A aggregation process, where amyloid fibrils are not only the end product of the process itself, but also act as catalysts for the formation of new aggregates (Michaels et al., 2020

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Selective knockdown of GAC did not affect cell growth and invasion compared to that in the control (shLuc) (Supplementary Fig