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In this commentary we discuss the novel findings of Gerner et al

We measured the total amounts of the TCA cycle metabolites succinate and malate, as well as the absolute amounts of the M + 2 isotopologues to rule out the possibility that the increase labelling (%) in subsequent turns of the TCA cycle is due to smaller pools of intermediates that would be labelled faster in the FTD3 neurons compared to the isogenic controls (Additionale file 2)

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It is also beneficial to the stabilization of hepatic microcirculation and prevents small-for-size liver graft failure 17

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