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Future research should also investigate the stability and variability of these quantitative descriptors across repeated measurements in the same individuals, in order to distinguish state-dependent fluctuations from trait-level regulatory patterns

In contrast, SCFAs (e.g., butyrate and propionate), which are derived from microbial fermentation of dietary fiber, exert protective effects by reducing inflammation and supporting EC integrity [190, 191]

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Therefore, a combination of transcellular and paracellular routes for crossing the nasopharyngeal barrier is also possible if the meningococci crossing via the transcellular route induce a sufficient level of inflammation to alter epithelial permeability, allowing other bacteria to follow the paracellular route