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Case series and cross-sectional studies further suggest that acne may represent an early cutaneous marker of systemic metabolic dysfunction, especially in adolescents and young adults (387, 388)

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doi: 10.1038/s41514-022-00083-0

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[80] addressed a contemporary challenge in the design of RNAi vectors by ensuring the incorporation of inverted repeats capable of generating double-stranded RNA (dsRNA) and eliciting a silencing effect in the host plant