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1995;75:71B-4B

This duality in p53 function with ROS intensity may decide the cell fate, with the protective arm of p53 activating processes to reduce cell stress with lower ROS intensity, while higher ROS intensity tips the balance towards cell death

Lehr HA, Frei B, Arfors KE (1994) Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo

Figure 2 While the young lens contains high levels of glutathione (GSH) to protect it from oxidative stress through direct neutralisation of ROS, the age-related decline in this key antioxidant makes the lens vulnerable to cataract formation

The exposure GWAS date of European populations varied from 2,603 to 428,860

Because iron chelators were shown to block this type of regulated cell death, it was originally defined as iron-dependent and was called "Ferroptosis" [1]