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J Physiol (Paris) 87:313327, 1993 Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Jagic V, Mildner M, Duvnjak M, Danilovic Z: Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl 4 administration

The reduction in total drug delivered to the systemic circulation is referred to as the First Pass Effect - reflecting the loss of drug via its first pass thru the GI tissues & liver before it reaches the systemic circulation

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If the distribution of confounding factors differs in the two arms, explicative regression analysis will be performed in which the dependent variable will be the normalisation of the serum vitamin B12 concentration, and the independent variable will be the treatment group

advanced references dose 250 mcg per injection, twice daily