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[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Wiggs K.K., Rickert M.E., Sujan A.C., Quinn P.D., Larsson H., Lichtenstein P., Oberg A.S., DOnofrio B.M

A 7-fold increase in bioavailability means that a 500 mcg oral dose of the arginate form could deliver the equivalent systemic exposure of approximately 3,500 mcg of the acetate form taken orally

Due to gradual patient accrual and a long period for analysis and FDA submission, some patients in the pivotal trial of every-other-day 250 mcg interferon-beta 1b were followed for up to 4 to 5 years (04)

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