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In vitro studies have suggested that fatty acid oxidation will be irregular when levels of tissue carnitine are below 10% of their normal level 9

Carnitine and Oxidative Stress Patients with advanced cancer experience oxidative stress, as evidenced by elevated ROS and decreased GPx levels [133]

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For an in-depth review on acylcarnitine functions and analysis methods, see our resource: Acylcarnitine Functions and Analysis Methods

Development of several experimental treatments have been initiated in the last number of years including pharmacological intervention and gene therapy, though comparisons of intervention efficacy across different trials is significantly hindered by different groups utilizing different outcome measures

It is well documented that CSP therapy is associated with increased excretion of a number of vital endogenous substances including LC [95,96]