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The 1-Cys Prdxs are resistant to hyperoxidation

Such a conformation is compatible with the very tight binding of NADPDHF to the enzyme 13 , while imposing a physical barrier for NADPH/ NADP + exchange during the reaction

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Due to its potent antioxidant activity, it combats oxidative stress in both the gastrointestinal tract and throughout the body, indicating further promise as a treatment for inflammatory diseases [2, 3, 4, 5, 6]

10.1016/j.bbr.2013.08.005 151 LammelS.HetzelA.HckelO.JonesI.LissB.RoeperJ