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Cancer Med (2019) 8:701831

ZhengZWhiteCLeeJPetersonTSBushAISunGYet al

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255 Similarly, new advances in synthetic biology, such as the development of synthetic Notch receptors that allow localized and tightly regulated delivery of genetically encoded therapeutics at precise sites of tissue pathology, 256 open the possibility for locally presenting TGF- inhibitors at sites of non-malignant TGF--driven diseases such as tissue fibrosis