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This reaction is called the Fenton reaction

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High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors

1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])

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