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RNA products were then gel-purified on a urea-polyacrylamide gel

Aberrant hypermethylation of these CpG sites may silence the expression of genes that are critical to cell homeostasis, DNA integrity, or genome stability, resulting in cancer development and progression [8]

Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism

This hypothetical mechanism also must be confirmed by experiments

Pritam P, Deka R, Bhardwaj A, Srivastava R, Kumar D, Jha AK, Jha NK, Villa C, Jha SK (2022) Antioxidants in Alzheimers disease: current therapeutic significance and future prospects

Reduce frequency or dose finding minimum sustaining benefits