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While preclinical studies suggest exosomes derived from young plasma can inhibit syn propagation and support neuronal health in PD models [304, 305], but challenges related to standardized production, targeted delivery, and immunogenicity remain to be addressed before clinical application

doi: 10.1038/sj.npp.1301133

Yes, bacteria in the mouth are normal, and most bacteria benefit our health

67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes
Any patient with chronic stress, inflammation, gut infection, mould, or poor methylation could be struggling with BH4 depletion
