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While circadian rhythms are not defined as a standalone hallmark of aging, their disruption intersects with multiple established hallmarks, such as chronic inflammation, mitochondrial dysfunction, epigenetic alterations, cellular senescence, and particularly psychosocial isolation, a newly proposed hallmark (Kroemer et al., 2025)

In the non-amyloidogenic pathway, alpha-secretase cleavage occurs in the A region, the C83 peptide is cleaved by -secretase, and then the amyloid beta fragment of the peptide is formed, which prevents the formation of A [61]

That's what they always call ADHD

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Journal of Molecular Histology 53 (1): 133143

doi: 10.1016/j.apsb.2021.10.005