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A technical apparatus called an isolation Chip (iChip) made it possible to cultivate these bacteria and, thus, to isolate and discover a novel class antibiotic, teixobactin [70], which is now in the preclinical stage of development

One of those willing to take on the challenge was Gustav Nossal (figure 16) who joined Burnet just as he was beginning to wrestle with Jerne's natural selection theory

It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling

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