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In the context of the Melanotan II pathway, this suggests that MC1R-mediated signaling is more likely to function within the expected range, supporting a more typical receptor response to melanocortin-family ligands such as -MSH analogs

MC3/MC5R: Possibly involved in energy balance, metabolism, and libido

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Proceedings of the University of Pennsylvania 7th annual conference on statistical issues in clinical trials: The use of biomarkers and surrogate endpoints in clinical trials

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