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Thus, the pharmacological inhibitors targeted ALOXs therapy should be used with caution, as many of them could neutralize with radicals and thus inhibit lipid peroxidation independently of ALOXs [35, 37]

Immunofluorescence staining of brain tissue examined the expression of tumor necrotic factor-alpha (TNF-, pro-inflammatory cytokine), glial fibrillary acidic protein (GFAP, a marker of activated astrocytes), sequestosome 1 (p62, marker of autophagic activity), voltage-dependent anion channel 1 (VDAC1, marker of mitochondrial stress), and NADPH Oxidase 4 (NOX4, marker of mitochondrial stress)

PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes

When natural levels fall too low, cellular protection weakens, potentially contributing to health problems

Some authors have shown an increase in endogenous antioxidant enzymes after exogenous SODs administration
Bone marrow transplantation 15 , 825828 (1995)