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A thorough understanding of RS requires further exploration through well-structured, methodologically rigorous clinical studies with adequate sample sizes to address current limitations [16, 26]

Selank reduces anxiety and subjective stress perception through GABA-ergic modulation, enhances cognitive performance and mental clarity under stress, supports emotional regulation and mood stability, and demonstrates neuroprotective effects that preserve cognitive function during stressful periods

Acknowledgments Financial support from FCT/MCTES through national funds UID/MULTI/04378/2019 and Norte Portugal Regional Coordination and Development Commission (CCDR-N)/NORTE2020/Portugal 2020 (Norte-01-0145-FEDER-000024) and a PhD grant (SRRH/BD/139622/2018) attributed to D

Before each injection of the solution, we carried out the aspiration with the needle to avoid intravascular application

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J Complement Integrat Med 10(1):1116 Akintunde J, Farai T, Arogundade M, Adeleke J (2021) Biogenic zinc-oxide nanoparticles of Moringa oleifera leaves abrogates rotenone induced neuroendocrine toxicity by regulation of oxidative stress and acetylcholinesterase activity