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Antioxidant therapeutics in parkinsons disease: current challenges and opportunities

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10.1111/j.1538-7836.2004.01085.x [DOI] [PubMed] [Google Scholar] 152.Lapenna D, de Gioia S, Ciofani G, Mezzetti A, Ucchino S, Calafiore AM, et al

The binding of antigen/MHC to the TCR complex results in the phosphorylation and activation of PLC1, which then hydrolyzes phospholipids at the plasma membrane to produce DAG and IP 3

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However, another clinical trial found that an 8-week course of curcumin with piperine did not significantly reduce serum pro-oxidantantioxidant balance (PAB) values, suggesting that the administered dose may have been insufficient to achieve a measurable reduction in oxidative stress (Mirhafez et al., 2019)