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One-way analysis of variance (ANOVA) followed by a least-significant difference (LSD) multiple range test was used to determine the statistical significance of multiple comparisons in the experiment

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Researchers studying semaglutide withdrawal patterns will recognize this as a significant limitation of all incretin-based therapies

McCoy and colleagues reported that 5-day treatment of dissociated rat hippocampal neurons with Dihexa increased dendritic spine density approximately three-fold compared to vehicle control (~41 spines per 50 m of dendrite versus ~15 spines), with the increase reflecting both new spine formation and increased spine-head width consistent with synaptic maturation [2]

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