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One interesting example is Pro 1150 located close to the beginning of CL7, which connects TM15 to TM16 (53)
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It also interacts strongly with testosterone
Prolonged angiogenic signaling may encourage unwanted vascular growth in tissues where balance is key (think: cancer cells use these same pathways to grow we want to avoid that) , especially if theres a history of cellular overgrowth or injury-prone tissue
10.1016/j.cell.2020.02.051 141 SarbassovD
Free radicals are highly reactive and can cause oxidative stress, which has been linked to various chronic diseases, such as cardiovascular diseases, certain cancers, and age-related macular degeneration [20]
