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In addition, the mitochondrial antioxidant superoxide dismutase (SOD2) has been largely associated with the prevention of atherosclerotic lesion through protecting mtDNA [165]

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In total, 2400 participants were given vitamin C (1000 mg) and vitamin E (400 IU) or the placebo from the moment of recruitment until delivery

It is typically thought to be well tolerated in animal research

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Additionally, hydrogen's small molecular size allows it to reach cellular compartments inaccessible to larger antioxidant molecules, providing protection to mitochondria and nuclei without requiring metabolic processing for elimination