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In the intestines, butyrate plays a regulatory role on the transepithelial fluid transport, ameliorates mucosal inflammation and oxidative status, reinforces the epithelial defense barrier, and modulates visceral sensitivity and intestinal motility (Canani et al., 2011)

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Additionally, extreme dietary interventions should be approached with caution and implemented under the supervision of qualified healthcare professionals, particularly because it is uncertain if they might exacerbate symptoms in ME/CFS patients, especially during the initial weeks

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