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Steady state studies varying NADPH and inhibitor concentrations indicate that treatment with the fast inhibitors 7 and 8 or the slow inhibitor 3 , (the only slow inhibitor reaching equilibrium in 6 h), resulted in decreases in both K m and V max values consistent with uncompetitive inhibition of TGR, while treatment with 9 , a close analog of compound 8 synthesized ad hoc to facilitate structural studies (see below), changed only the V max indicating noncompetitive inhibition (Supplementary Tables 15 and 16)

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Gianaros P.J., Jennings J.R., Sheu L.K., Derbyshire S.W.G., Matthews K.A

(2014) 12:e17954

Ismail, R

2020;26(2):e3234.

Understanding the interaction between fluid dynamics and ligament mechanics can lead to better injury prevention and treatment strategies