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Sumien N, Cunningham JT, Davis DL, Engelland R, Fadeyibi O, Farmer GE, et al

What puts the heat on thermogenic fat: metabolism of fuel substrates

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4.3 The vicious cycle of metabolic deficits and immune activation Mitochondrial dysfunction may result in overproduction of ROS and the release of mtDNA, both of which serve as DAMPs, activating the NLRP3 inflammasome in both peripheral and central immune systems, thereby promoting the release of pro-inflammatory cytokines, such as IL-1 and IL-18 (168170)