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The appetite-suppression mechanism is what makes semaglutide so much more powerful than AOD-9604 for weight management

BioWorld - Friday, July 17, 2026 Breaking News: Best of BioWorld Science: Q2See today's BioWorld Science Home Metabolic completes dosing in AOD-9604 phase IIb trial To read the full story, subscribe or sign in

For gastrointestinal applications, digestive comfort may improve within the first 1 to 2 weeks, progressing to sustained improvements in food tolerances by weeks 5 to 6

10.1186/s13287-020-01914-1 33 Garcia-LlorensG.Martnez-SenaT.ParejaE.TolosaL.CastellJ

Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear