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We performed statistical analyses using GraphPad Prism 8.0

The primary mechanism underlying ferroptosis is the accumulation of iron and lipid peroxidation, leading to a perturbation of oxidative homeostasis within the cellular microenvironment [220]

International journal of preventive medicine

Inflammatory Mediators Cytokines are important cell signaling molecules secreted by a variety of immune cells, both innate and adaptive, in response to infection and inflammation [1]

The transplanted human mesenchymal stem cells survived for at least six months and demonstrated expression of chondrocyte markers and mRNA expression of collagen IIA, IIB, versican, aggrecan, and Sox9 indicating differentiation into disc-like cells

Overall, safety hinges on dosing to phenotype, respecting phase-of-disease timing and coordinating with therapies that intentionally leverage oxidative mechanisms (2022