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This is a feature of congestive failure not lipedema, agree

Free Radic Biol Med 110:240249
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Meanwhile, following a prolonged period of erastin treatment, VDAC2/3 failed to be detected in the cells and such reduced expression resulted in erastin resistance (Yagoda et al., 2007)

Glycine will bind to GcvR, causing it to release GcvA
