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Specifically, pigs and ferrets are considered high-fidelity models because of their lung anatomy, physiology, and pathology (including spontaneous bacterial infections, inflammation, and mucus plugging) closely recapitulate the human CF condition from birth

Cloning and Characterization of the Murine Histone Deacetylase (HDAC3)

The in vivo metabolism of INH involving theNH 2 functional group is understood to be a significant cause for this

GST enzymes also play an important role in detoxifying chemotherapy drugs (17)