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RNA-seq analysis of hippocampal postmortem brain samples revealed a significant increase in MMP9 expression in male children with ASD compared to healthy controls [41]

Importantly, the anti-apoptotic property of TUDCA could be exerted by interfering with upstream signal of mitochondria apoptosis

The observation that replacement of the N-terminal norleucine with GABA yielded a compound with superior antidementia activity indicated that an N-terminal -amino group was not required for activity

When the body takes a large oxidative hit, active glutathione is depleted, and the result is widespread oxidative damage

This suggests that GSTP1 may be able to delay disease progression in PD

F.KieperN.MaurerB.WaakJ.et al (2010)