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Although these conclusions appeared to be justified based on the reported experiments, it again raised the issue of questionable neutropenia experiments111,115, and the findings contradicted previous data showing that IL-1 receptor-deficient mice were not protected123, that total elimination of Kupffer cells actually enhanced APAP-induced liver injury125,126, and that TLR9120,121 and TLR3127 are important for the pathophysiology

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Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ: Review article: the role of butyrate on colonic function