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Nutritional supplements such as branched-chain amino acids (BCAA: valine, leucine, isoleucine) along with a balanced diet, lead to the synthesis of proteins, structural elements in muscles, and increased gains in lean mass

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Since GPX4 relies on GSH to neutralize lipid peroxides, lactate-driven metabolic reprogramming may indirectly compromise GPX4 efficiency, rendering PASMCs more susceptible to ferroptotic stimuli
