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10.1021/acs.chemrestox.8b00026 84 RavindranathV.BurkaL

doi: 10.18632/aging.102210

Long-term treatment of Laron type dwarfs with insulin-like growth factor-1 increases serum insulin-like growth factor-binding protein-3 in the absence of growth hormone activity

The latter modification is consistent with our recent report that parkin thiols participate in redox chemistry to neutralize highly reactive molecules , e.g., H 2 O 2 and dopamine metabolites [53], as well as with the literature on transient S- glutathionylation of redox-sensitive proteins as a cytoprotective mechanism against rising concentrations of ROS [27]

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Just like cyanocobalamin, it has to be reduced from state +3 to +1 before it can become either methyl B12 or adenosyl B12