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A 2025 clinical update reinforced prior evidence that B12 supplementation, including injections, does not improve energy or cognitive performance in non-deficient individuals

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However, a larger follow-up pivotal trial, known as METAOD006 (or OPTIONS), enrolled a bigger cohort and failed to replicate statistically significant weight loss, leading the sponsoring company, Metabolic Pharmaceuticals, to halt the formal drug-development program in 2007