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Through its conversion to ornithine and proline, arginine directly supplies the substrates required for collagen biosynthesis, positioning it as a metabolic driver of ECM accumulation [13,14,15,16]

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It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs)