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Resistance mechanisms to these drugs have been identified that result in restoration of AR signalling through gain-of-function AR mutations, upregulation of constitutively active AR splice variants or increased intratumoural androgen biosynthesis

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A high C rate LiPo battery is one that is designed to handle a significantly higher discharge current compared to standard batteries.In practical terms, a high C rate LiPo battery is capable of delivering more power in a shorter amount of time, making it suitable for applications that demand quick bursts of energy or high-performance requirements