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mir-29b is a key suppressor of many downstream target genes involved in fibrogenesis, including COL1A1, COL3A1, and FBN1, which are regulated by the TGF-b/smad3 pathway, and transfection with miR-29 mimics and miR-29 inhibitors suggests that miR-29 regulates the expression of mortality receptor Fas, leading to apoptosis [326, 327]

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The unique lamellar structure of LDHs, characterized by high surface-to-volume ratios and adjustable interlayer spacing, endows them with superior drug-loading capacity [25]

Caro JF, Poulos J, Ittoop O, Pories WJ, Flickinger EG, Sinha MK: Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver

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Another trial showed NAC (600 mg 2 daily) increased cellular glutathione by 35% and reduced oxidative stress markers by 25% [9]