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There are many other studies on this topic and its probably beyond the scope of this blog

Most people find that by weeks seven and eight, their gastrointestinal symptoms at the 0.5mg level are considerably more manageable than they were in weeks five and six

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8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years

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