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Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants

2014;24(10):R453R462

Complex II subunit SDHD is critical for cell growth and metabolism, which can be partially restored with a synthetic ubiquinone analog

Cytochrome b5 reductase (CBR) deficiency is an enzymopathy that does not cause hemolytic anemia: it instead causes recessive congenital methemoglobinemia, 29 often presenting as cyanosis in infants, that may mislead one to suspect congenital heart disease

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Molecular mechanisms of quinone cytotoxicity