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Recent studies suggest that PQQ activates SIRT1 and SIRT3 genes and increases NAD + activity in the human hepatocyte cell line HepG2 41 , induces deacetylation of PGC-1 and enhancement of mitochondrial activity in NIH/3T3 cells after treatment with a SIRT1 selective inhibitor 76 , and protects skeletal muscles from denervation-induced atrophy by activating PGC-1 and improving the energy metabolic profile in C57BL6/J mice 77

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It has two stereoisomers: bioactive L-carnitine and abiotic enantiomeric isomer D-carnitine

Fleisher DR, Matar M

* Nutrient Reference Value according to Regulation (EU) 1169/2011 ** No reference value available You are currently viewing a placeholder content from Facebook

L-carnitine metabolism to GBB, crotonobetaine, and TMA (and ultimately TMAO) could affect L-carnitine availability for bioenergetics, particularly if biosynthesis is also impaired and/or there is an increased reliance in FAO for energy production (i.e., an increased demand for L-carnitine)